Skincare Ingredient Facts – Tranexamic Acid
Here at Mountain Coast we like to keep you up to date on the latest advances in skin care ingredients.
This Post it’s Tranexamic Acid!
Tranexamic acid is a synthetic derivative of the amino acid lysine. It inhibits the breakdown of fibrin through the reversible blockade of lysine binding sites on plasminogen molecules. It was originally designed as a drug to reduce blood loss after surgery.
Tranexamic acid has more recently demonstrated a curative effect towards melasma and ultraviolet-induced PIH in Asian countries.
In a recent Clinical Trial: Melan-a cells and human melanocytes were cultured with fractional CO2 laser-treated keratinocyte-conditioned media. Melanin content and tyrosinase activity were evaluated in cells treated with or without tranexamic acid. Protein levels of tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 were evaluated in melan-a cells. Signaling pathway molecules involved in melanogenesis in melanoma cells were also investigated.
Tranexamic acid-treated melanocytes exhibited reduced melanin content and tyrosinase activity. Tranexamic acid also decreased tyrosinase, TRP-1, and TRP-2 protein levels. Conclusion
Tranexamic acid may be an attractive candidate for skin lightening and the treatment of PIH.
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