Blinded, Controlled Trials on how effectively masks reduce transmission of respiratory viruses
Read the only Blinded, Controlled Trials regarding how effective face coverings are against the transmission of respiratory viruses:
Jacobs, J. L. et al. (2009) â€œUse of surgical face masks to reduce the incidence of the common cold among health care workers in Japan: A randomized controlled trial,â€ American Journal of Infection Control, Volume 37, Issue 5, 417 â€“ 419. https://www.ncbi.nlm.nih.gov/pubmed/19216002
N95-masked health-care workers (HCW) were significantly more likely to experience headaches. Face mask use in HCW was not demonstrated to provide benefit in terms of cold symptoms or getting colds.
Cowling, B. et al. (2010) â€œFace masks to prevent transmission of influenza virus: A systematic review,â€ Epidemiology and Infection, 138(4), 449-456. https://www.cambridge.org/core/journals/epidemiology-and-infection/article/face-masks-to-prevent-transmission-of-influenza-virus-a-systematic- review/64D368496EBDE0AFCC6639CCC9D8BC05
None of the studies reviewed showed a benefit from wearing a mask, in either HCW or community members in households (H). See summary Tables 1 and 2 therein.
bin-Reza et al. (2012) â€œThe use of masks and respirators to prevent transmission of influenza: a systematic review of the scientific evidence,â€ Influenza and Other Respiratory Viruses 6(4), 257â€“267. https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1750-2659.2011.00307.x
â€œThere were 17 eligible studies. â€¦ None of the studies established a conclusive relationship between mask/respirator use and protection against influenza infection.â€
Smith, J.D. et al. (2016) â€œEffectiveness of N95 respirators versus surgical masks in protecting health care workers from acute respiratory infection: a systematic review and meta-analysis,â€ CMAJ Mar 2016 https://www.cmaj.ca/content/188/8/567
â€œWe identified six clinical studies â€¦ . In the meta-analysis of the clinical studies, we found no significant difference between N95 respirators and surgical masks in associated risk of (a) laboratory-confirmed respiratory infection, (b) influenza-like illness, or (c) reported work-place absenteeism.â€
Offeddu, V. et al. (2017) â€œEffectiveness of Masks and Respirators Against Respiratory Infections in Healthcare Workers: A Systematic Review and Meta-Analysis,â€ Clinical Infectious Diseases, Volume 65, Issue 11, 1 December 2017, Pages 1934â€“1942, https://academic.oup.com/cid/article/65/11/1934/4068747
Self-reported assessment of clinical outcomes was prone to bias. Evidence of a protective effect of masks or respirators against verified respiratory infection (VRI) was not statistically significantâ€; as per Fig. 2c therein:
Radonovich, L.J. et al. (2019) â€œN95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial,â€ JAMA. 2019; 322(9): 824â€“833. https://jamanetwork.com/journals/jama/fullarticle/2749214
â€œAmong 2862 randomized participants, 2371 completed the study and accounted for 5180 HCW-seasons. â€¦ Among outpatient health care personnel, N95 respirators vs medical masks as worn by participants in this trial resulted in no significant difference in the incidence of laboratory-confirmed influenza.â€
Long, Y. et al. (2020) â€œEffectiveness of N95 respirators versus surgical masks against influenza: A systematic review and meta-analysis,â€ J Evid Based Med. 2020; 1- 9. https://onlinelibrary.wiley.com/doi/epdf/10.1111/jebm.12381
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